Disease models

We aim to make disease models accessible to the worldwide research community. To that end, we acquire, develop, and characterize new models, and distribute them through public repositories.

Models currently available include cell lines and several types of xenograft models representing many of the clinical manifestations of the disease. This includes models derived from primary, recurrent, and metastatic tumors of multiple anatomic locations from children and adults.

Importantly, all models available from our repositories are rigorously characterized to ensure that they are actually derived from chordoma tumors and are properly identified.

Access to model sequencing data

Data resulting from genomic characterization of our cell lines and PDX models is available in Cavatica. To access the Chordoma Foundation Dataset, create an account, log in, and submit a data access request. Processed and easily queryable model sequencing data is also available in PedcBioPortal.

General chordoma cell culture protocols

CF Labs developed and vetted protocols to optimize chordoma cell culture and experiments. Contact us if you need assistance.

1. Thawing cells 2. Freezing cells 3. Collagen coating flasks

Cell line repository

We partner with the American Type Culture Collection (ATCC) to maintain and distribute chordoma cell lines through their global distribution channels. Many of these cell lines are available through ATCC’s General Collection and may be purchased on the ATCC website. For cell lines that cannot be made available through ATCC’s General Collection, we maintain a private repository at ATCC; cell lines in this collection are available via a material transfer agreement with the Chordoma Foundation.

See the table below for details on available cell lines and how they can be obtained. Click the name of a cell line for more details including clinical data and culture instructions.

To request cell lines requiring an MTA, contact us. Requests involving multiple disease models that use identical MTA terms (such as U-CH or UM-Chor cell lines) may be consolidated into a single MTA document. In such cases, please specify each model requested in the draft MTA.

Cell Line	Disease Origin	Disease Status	Age	Availability
U-CH1	Sacral	Recurrent	56	ATCC
U-CH2	Sacral	Recurrent	72	ATCC
U-CH6	Sacral	Recurrent + Metastatic	56	Download MTA
U-CH7	Sacral	Primary	67	ATCC
U-CH11	Sacral	Primary	71	Download MTA
U-CH11R	Sacral	Recurrent	75	ATCC
U-CH12	Sacral	Primary	83	ATCC
U-CH17P	Sacral	Metastatic	38	Download MTA
U-CH17PII	Sacral	Metastatic	38	Download MTA
U-CH17M	Sacral	Metastatic	38	ATCC
U-CH17S	Sacral	Metastatic	38	ATCC
U-CH18	Thoracic	Recurrent	56	Download MTA
U-CH19	Sacral	Primary	77	ATCC
CH22	Sacral	Recurrent + Metastatic	56	Download MTA
JHC7	Sacral	Primary	61	ATCC
MUG-Chor1	Sacral	Recurrent	57	ATCC
MUG-CC1	Clival	Primary	72	ATCC
U-CH14	Clival	Primary	79	Download MTA
UM-Chor1	Clival	Primary	66	ATCC
UM-Chor5	Clival	Primary	<20	ATCC
UM-Chor5C	Clival	Recurrent + Metastatic	<20	ATCC
UM-Chor5D	Clival	Recurrent + Metastatic	<20	ATCC
UM-Chor6	Clival	Primary	32	Download MTA
U-CHCF359B	Clival	Recurrent + Metastatic	<20	ATCC
U-CHCF365	Clival	Recurrent + Metastatic	<20	ATCC
13425-306	Cervical	Metastatic	21	Available soon

PDX repository

We partner with the contract research organization XenoSTART in San Antonio, TX to maintain and distribute cell line-derived xenograft (CDX) and patient-derived xenograft (PDX) models of chordoma. Currently available PDX models are listed below. Click the name of the model for more details including clinical data and culture instructions.

To request models contact us. Requests involving multiple disease models that use identical MTA terms (CF or SF PDX models) may be consolidated into a single MTA document. In such cases, please specify each model requested in the draft MTA.

In addition to the PDX models listed below, cell line derived xenograft models have been developed from the U-CH1 and CH22 cell lines. A humanized model of the U-CH1 cell line has also been developed. Contact us for more information.

Acknowledgements

We are deeply grateful to the patients who donated their tumor tissue from which these models are derived, to the researchers who painstakingly created them, and to the many donors who have contributed to making them available to the research community.

PDX Model	Disease Origin	Disease Status	Age	Availability
SF8894	Clival	Recurrent	59	Download MTA
CF322	Clival	Recurrent	42	Download MTA
CF365	Clival	Recurrent + Metastatic	<20	Download MTA
CF359B	Clival	Recurrent + Metastatic	<20	Download MTA
CF382	Clival	Recurrent + Metastatic	57	Download MTA
CF459	Clival	Primary	<20	Download MTA
CF538	Clival	Recurrent + Metastatic	<20	Download MTA
CF539	Clival	Recurrent + Metastatic	<20	Download MTA
CF555	Clival	Recurrent + Metastatic	<20	Download MTA
CF427	Clival	Primary	55	Download MTA
CF466	Lumbar	Recurrent + Metastatic	58	Download MTA
CF522	Sacral	Primary	59	Download MTA
SF10792	Clival	Primary	61	Download MTA

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