General Characteristics
| Age: | <20 years |
| Gender: | Male |
| Disease origin: | Clival |
| Disease status: | Primary |
| Prior radiation: | No |
| Prior systemic therapy: | No |
| Source: | Chordoma Foundation/START |
| Notes: | This PDX model is part of a progression model from the same patient; CF459 was derived from the primary clival chordoma. Other PDX models in this longitudinal series include CF538 (recurrent neck metastasis), CF539 (recurrent parotid metastasis) and CF555 (local recurrence). Timeline of tumor samples is: CF459 => CF538, CF539 => CF555. |
Molecular Features
| Histological subtype: | Conventional |
| Histology features: | TBXT, H&E |
| Sequence data: | PedcBioPortal |
| SMARCB1 status: | truncating mutation Lys16* |
| Notable genomic alterations: |
Growth Characteristics
| Model animal strain: | Nude |
Publications
- Not yet published