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U-CH12

General Characteristics

Age: 83 years
Gender: Male
Disease Origin: Sacral
Disease Status: Primary
Prior Radiation: No
Prior Systemic Therapy: No
Source: Silke Bruderlein, Peter Moller
University of Ulm

Molecular Features

Cell Morphology: Physaliferous
TBXT Expression: Positive; 13x that of U-CH2
TBXT Localization: Nuclear
CD24 Expression: Positive; 10x that of U-CH2
HLA Type:
Sequence Data:

Exome and transcriptome data available: raw sequencing data in Cavatica (Chordoma Foundation Dataset) and summary data in PedcBioportal. Contact researchteam@chordoma.org with any questions.

SMARCB1 Status:
Validation Results: Validation Report

Growth Conditions

Growth Medium: IMDM: RPMI-1640 (4:1) +10% FBS
Freeze Medium: 70% complete growth medium supplemented with an additional 20% fetal bovine serum and 10% DMSO
Culture Conditions: Temperature: 37°C
Atmosphere: air, 95%; carbon dioxide (CO2), 5%
Subculturing Instructions: Cell Culture Procedures

Publications

Characterized By:
  • Cancer Res. 2015 Sep 15;75(18):3823-31. doi: 10.1158/0008-5472.CAN-14-3270. Epub 2015 Jul16. Preclinical Characterization of Novel Chordoma Cell Systems and Their Targeting byPharmocological Inhibitors of the CDK4/6 Cell-Cycle Pathway. von Witzleben A1